Most seem to be caused by a complex mix of risk factors, some environmental and some genetic or hereditary.įor most cases of soft tissue sarcomas, no direct cause has been determined for their development. Very few tumors and cancers have a single known cause. The reason why a particular pet may develop this, or any tumor or cancer, is not straightforward.
#Spindle cell sarcoma in dogs skin
"Soft tissue sarcomas make up about 15% of cancers of the skin affecting dogs and about 7% of those affecting cats."Įven though soft tissue tumors arise from many different types of cells, they all behave in a similar manner and their treatment is typically the same. Fibrosarcomas are common in dogs and are a type of soft tissue sarcoma (see handout "Fibrosarcoma in Dogs" for more information). Soft tissue sarcomas make up about 15% of cancers of the skin affecting dogs and about 7% of those affecting cats. Connective, muscle, and nervous tissues are present throughout the entire body therefore, these tumors can develop over the chest, back, side, legs, and facial tissues of your pet. These tumors are the result of abnormal production of these cell types in an uncontrolled manner. The relationship between spindle cell tumors of the anterior uvea of dogs, altered neural crest, blue iris color, and ultraviolet radiation has not yet been fully elucidated.Soft tissue sarcomas are a broad category of tumors including those that arise from the connective, muscle, or nervous tissues in dogs and cats. These tumors are morphologically and immunohistochemically most consistent with schwannoma. Electron microscopy revealed intermittent basal laminae between cells. Tumors were variably positive for PGP 9.5, laminin, gadd45, p53, PCNA, anti-UVssDNA, and TERT. All tumors were negative for SMA, desmin, Melan A, and MITF-1. Nine of 13 tumors exhibited GFAP immunopositivity. All tumors were positive when immunostained for vimentin and S-100. All tumors occurred in the iris with or without ciliary body involvement and were composed of spindle cells arranged in fascicles and whorls (variable Antoni A and B behavior). Immunohistochemical staining included alpha-smooth muscle actin (SMA), vimentin, S-100, desmin, glial fibrillary acidic protein (GFAP), Melan A, microphthalmic transcription factor (MITF-1), protein gene product 9.5 (PGP 9.5), laminin, gadd45, p53, proliferating cell nuclear antigen (PCNA), anti-UVssDNA (antibody for detection of (6-4)-dipyrimidine photoproducts), and telomerase reverse transcriptase (TERT).
Light microscopic evaluation (all dogs) and electron microscopy (2 dogs) were performed. Siberian Husky and Siberian Husky mix dogs were overrepresented (10/13 dogs, overall median age 10 years). Thirteen tumors were identified from the 4,007 canine ocular samples examined at the Comparative Ocular Pathology Laboratory of Wisconsin between 19. Immunohistochemical techniques were used to investigate the origin of a spindle cell tumor in the anterior uveal tract of dogs and the influence of ultraviolet radiation on the development of this tumor.
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